7A3T

Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8

7A3T の概要

• エントリーDOI: 10.2210/pdb7a3t/pdb
• 関連するPDBエントリー: 7A3N 7A3O 7A3P 7A3Q 7A3R 7A3S 7A3U 7CTH
• 分子名称: Core protein, EDE1 C8 antibody Fab fragment, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: viral protein, flavivirus, class 2 fusion protein, dengue, antibody
• 由来する生物種: Dengue virus 3; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 101288.13

構造登録者

Sharma, A.,Vaney, M.C.,Guardado-Calvo, P.,Duquerroy, S.,Rouvinski, A.,Rey, F.A. (登録日: 2020-08-18, 公開日: 2021-12-08, 最終更新日: 2024-01-31)

• 主引用文献: Sharma, A.,Zhang, X.,Dejnirattisai, W.,Dai, X.,Gong, D.,Wongwiwat, W.,Duquerroy, S.,Rouvinski, A.,Vaney, M.C.,Guardado-Calvo, P.,Haouz, A.,England, P.,Sun, R.,Zhou, Z.H.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A.; The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses.; Cell, 184:6052-6066.e18, 2021; PubMed: 34852239; DOI: 10.1016/j.cell.2021.11.010

実験手法

X-RAY DIFFRACTION (2.65 Å)