7A3T
Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Core protein | polymer | 428 | 46759.1 | 1 | UniProt (A0A481XTQ0) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (P27915) In PDB | Dengue virus 3 | Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M |
2 | H | EDE1 C8 antibody Fab fragment | polymer | 272 | 28882.8 | 1 | Homo sapiens (Human) | ||
3 | L | EDE1 C8 antibody Fab fragment | polymer | 217 | 23998.7 | 1 | Homo sapiens (Human) | ||
4 | B | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G00395TQ) | |||
5 | A, H | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
6 | A, L | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
7 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 393 (UniProt: A0A481XTQ0)
PDB | External Database | Details |
---|---|---|
Cys 107 | Leu 387 | engineered mutation |
Cys 311 | Ser 591 | engineered mutation |
Leu 394 | - | expression tag |
Val 395 | - | expression tag |
Pro 396 | - | expression tag |
Arg 397 | - | expression tag |
Gly 398 | - | expression tag |
Ser 399 | - | expression tag |
Ser 400 | - | expression tag |
Ala 401 | - | expression tag |
Trp 402 | - | expression tag |
Ser 403 | - | expression tag |
His 404 | - | expression tag |
Pro 405 | - | expression tag |
Gln 406 | - | expression tag |
Phe 407 | - | expression tag |
Glu 408 | - | expression tag |
Lys 409 | - | expression tag |
Gly 410 | - | expression tag |
Gly 411 | - | expression tag |
Ser 412 | - | expression tag |
Gly 413 | - | expression tag |
Gly 414 | - | expression tag |
Gly 415 | - | expression tag |
Ser 416 | - | expression tag |
Gly 417 | - | expression tag |
Gly 418 | - | expression tag |
Ser 419 | - | expression tag |
Ala 420 | - | expression tag |
Trp 421 | - | expression tag |
Ser 422 | - | expression tag |
His 423 | - | expression tag |
Pro 424 | - | expression tag |
Gln 425 | - | expression tag |
Phe 426 | - | expression tag |
Glu 427 | - | expression tag |
Lys 428 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 99640.7 | |
Branched | Number of molecules | 1 |
Total formula weight | 894.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 752.6 | |
All* | Total formula weight | 101288.1 |