7A3T
Crystal structure of dengue 3 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Core protein | polymer | 428 | 46759.1 | 1 | UniProt (A0A481XTQ0) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (P27915) | Dengue virus 3 | Envelope protein E,Flavivirin protease NS2B regulatory subunit,Flavivirin protease NS3 catalytic subunit,Genome polyprotein,Matrix protein,Non-structural protein 1,Non-structural protein 2A,Non-structural protein 2B,Non-structural protein 3,Non-structural protein 4A,Non-structural protein 4B,Peptide 2k,Peptide pr,Protein prM,RNA-directed RNA polymerase NS5,Serine protease NS3,Serine protease subunit NS2B,Small envelope protein M |
| 2 | B (H) | EDE1 C8 antibody Fab fragment | polymer | 272 | 28882.8 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | EDE1 C8 antibody Fab fragment | polymer | 217 | 23998.7 | 1 | Homo sapiens (Human) | ||
| 4 | D (B) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G00395TQ) | |||
| 5 | E, F, J, K (A, H) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | G, H, I, L (A, L) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | M, N, O (A, H, L) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 393 (UniProt: A0A481XTQ0)
| PDB | External Database | Details |
|---|---|---|
| Cys 107 | Leu 387 | engineered mutation |
| Cys 311 | Ser 591 | engineered mutation |
| Leu 394 | - | expression tag |
| Val 395 | - | expression tag |
| Pro 396 | - | expression tag |
| Arg 397 | - | expression tag |
| Gly 398 | - | expression tag |
| Ser 399 | - | expression tag |
| Ser 400 | - | expression tag |
| Ala 401 | - | expression tag |
| Trp 402 | - | expression tag |
| Ser 403 | - | expression tag |
| His 404 | - | expression tag |
| Pro 405 | - | expression tag |
| Gln 406 | - | expression tag |
| Phe 407 | - | expression tag |
| Glu 408 | - | expression tag |
| Lys 409 | - | expression tag |
| Gly 410 | - | expression tag |
| Gly 411 | - | expression tag |
| Ser 412 | - | expression tag |
| Gly 413 | - | expression tag |
| Gly 414 | - | expression tag |
| Gly 415 | - | expression tag |
| Ser 416 | - | expression tag |
| Gly 417 | - | expression tag |
| Gly 418 | - | expression tag |
| Ser 419 | - | expression tag |
| Ala 420 | - | expression tag |
| Trp 421 | - | expression tag |
| Ser 422 | - | expression tag |
| His 423 | - | expression tag |
| Pro 424 | - | expression tag |
| Gln 425 | - | expression tag |
| Phe 426 | - | expression tag |
| Glu 427 | - | expression tag |
| Lys 428 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 99640.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 894.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 752.6 | |
| All* | Total formula weight | 101288.1 |
