7UMB
NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex
Summary for 7UMB
Entry DOI | 10.2210/pdb7umb/pdb |
Descriptor | Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | tracer, kinase, complex, mek1, ksr2, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 84924.13 |
Authors | Marsiglia, W.M.,Khan, K.M.,Dar, A.C. (deposition date: 2022-04-06, release date: 2023-09-27, Last modification date: 2024-03-20) |
Primary citation | Marsiglia, W.M.,Chow, A.,Khan, Z.M.,He, L.,Dar, A.C. Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes. Nat.Chem.Biol., 20:373-381, 2024 Cited by PubMed: 37919548DOI: 10.1038/s41589-023-01454-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.231 Å) |
Structure validation
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