7SZD

Crystal Structure Analysis of human PRPK complex with a compound

Summary for 7SZD

• Entry DOI: 10.2210/pdb7szd/pdb
• Descriptor: EKC/KEOPS complex subunit TP53RK, EKC/KEOPS complex subunit TPRKB, 2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid, ... (4 entities in total)
• Functional Keywords: protein kinase, p53, immunomodulatory drugs, imids, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 97302.27

Authors

Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2021-11-27, release date: 2022-12-14, Last modification date: 2024-02-07)

• Primary citation: Seo, H.-S.,Mizutani, T.,Hideshima, T.,Vangos, N.E.,Zhang, T.,Anderson, K.C.,Gray, N.S.,Dhe-Paganon, S.; Development of PRPK Directed Phthalimides; Biorxiv, 2021; DOI: 10.1101/2021.11.30.469594

Experimental method

X-RAY DIFFRACTION (2.05 Å)