Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7SZD

Crystal Structure Analysis of human PRPK complex with a compound

Functional Information from GO Data
ChainGOidnamespacecontents
A0000408cellular_componentEKC/KEOPS complex
A0002039molecular_functionp53 binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0008033biological_processtRNA processing
A0016787molecular_functionhydrolase activity
A0035175molecular_functionhistone H3S10 kinase activity
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035979molecular_functionhistone H2AXS139 kinase activity
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0070525biological_processtRNA threonylcarbamoyladenosine metabolic process
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0106310molecular_functionprotein serine kinase activity
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A1901796biological_processregulation of signal transduction by p53 class mediator
A1990244molecular_functionhistone H2AT120 kinase activity
B0000408cellular_componentEKC/KEOPS complex
B0002949biological_processtRNA threonylcarbamoyladenosine modification
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008033biological_processtRNA processing
B0019901molecular_functionprotein kinase binding
C0000408cellular_componentEKC/KEOPS complex
C0002039molecular_functionp53 binding
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004676molecular_function3-phosphoinositide-dependent protein kinase activity
C0004677molecular_functionDNA-dependent protein kinase activity
C0004679molecular_functionAMP-activated protein kinase activity
C0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
C0004711molecular_functionribosomal protein S6 kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006338biological_processchromatin remodeling
C0006468biological_processprotein phosphorylation
C0008033biological_processtRNA processing
C0016787molecular_functionhydrolase activity
C0035175molecular_functionhistone H3S10 kinase activity
C0035402molecular_functionhistone H3T11 kinase activity
C0035403molecular_functionhistone H3T6 kinase activity
C0035979molecular_functionhistone H2AXS139 kinase activity
C0044022molecular_functionhistone H3S28 kinase activity
C0044023molecular_functionhistone H4S1 kinase activity
C0044024molecular_functionhistone H2AS1 kinase activity
C0044025molecular_functionhistone H2BS14 kinase activity
C0070525biological_processtRNA threonylcarbamoyladenosine metabolic process
C0072354molecular_functionhistone H3T3 kinase activity
C0072371molecular_functionhistone H2AS121 kinase activity
C0072518molecular_functionRho-dependent protein serine/threonine kinase activity
C0106310molecular_functionprotein serine kinase activity
C0140823molecular_functionhistone H2BS36 kinase activity
C0140855molecular_functionhistone H3S57 kinase activity
C0140857molecular_functionhistone H3T45 kinase activity
C1901796biological_processregulation of signal transduction by p53 class mediator
C1990244molecular_functionhistone H2AT120 kinase activity
D0000408cellular_componentEKC/KEOPS complex
D0002949biological_processtRNA threonylcarbamoyladenosine modification
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0008033biological_processtRNA processing
D0019901molecular_functionprotein kinase binding
Functional Information from PROSITE/UniProt
site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LIHgDLTTSNMLL
ChainResidueDetails
ALEU158-LEU170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP162
CASP162

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AVAL39
ALYS60
CVAL39
CLYS60

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER34
CSER34

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATHR135
CTHR135

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon