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7SZD

Crystal Structure Analysis of human PRPK complex with a compound

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, CEKC/KEOPS complex subunit TP53RKpolymer25528358.62UniProt (Q96S44)
Pfam (PF06293)
In PDB
Homo sapiens (Human)Atypical serine/threonine protein kinase TP53RK,Nori-2,TP53-regulating kinase,p53-related protein kinase
2B, DEKC/KEOPS complex subunit TPRKBpolymer17819976.22UniProt (Q9Y3C4)
Pfam (PF08617)
In PDB
Homo sapiens (Human)PRPK-binding protein,TP53RK-binding protein
3A, C2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acidnon-polymer316.32Chemie (DVO)
4waterwater18.048Chemie (HOH)
Sequence modifications
A, C: 1 - 253 (UniProt: Q96S44)
PDBExternal DatabaseDetails
Gly -1-expression tag
Pro 0-expression tag
B, D: 1 - 175 (UniProt: Q9Y3C4)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight96669.7
Non-Polymers*Number of molecules2
Total formula weight632.5
All*Total formula weight97302.3
*Water molecules are not included.

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PDB entries from 2024-09-11

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