7RAN
5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Summary for 7RAN
Entry DOI | 10.2210/pdb7ran/pdb |
EMDB information | 24378 |
Descriptor | 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | 5-ht2a receptor, serotonin receptor, g protein, gpcr, novel agonist, cryoem, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 142403.71 |
Authors | Barros-Alvarez, X.,Kim, K.,Panova, O.,Roth, B.L.,Skiniotis, G. (deposition date: 2021-07-02, release date: 2022-07-06, Last modification date: 2022-11-02) |
Primary citation | Kaplan, A.L.,Confair, D.N.,Kim, K.,Barros-Alvarez, X.,Rodriguiz, R.M.,Yang, Y.,Kweon, O.S.,Che, T.,McCorvy, J.D.,Kamber, D.N.,Phelan, J.P.,Martins, L.C.,Pogorelov, V.M.,DiBerto, J.F.,Slocum, S.T.,Huang, X.P.,Kumar, J.M.,Robertson, M.J.,Panova, O.,Seven, A.B.,Wetsel, A.Q.,Wetsel, W.C.,Irwin, J.J.,Skiniotis, G.,Shoichet, B.K.,Roth, B.L.,Ellman, J.A. Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature, 610:582-591, 2022 Cited by PubMed: 36171289DOI: 10.1038/s41586-022-05258-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.45 Å) |
Structure validation
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