7RAN
5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 2A | polymer | 339 | 38274.3 | 1 | UniProt (P28223) Pfam (PF00001) | Homo sapiens (Human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A |
| 2 | B (B) | G protein subunit q (Gi2-mini-Gq chimera) | polymer | 246 | 28084.8 | 1 | Homo sapiens (Human) | ||
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (E) | single-chain variable fragment 16 (scFv16) | polymer | 286 | 30552.2 | 1 | Homo sapiens (Human) | ||
| 6 | F (A) | (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium | non-polymer | 214.3 | 1 | Chemie (3IQ) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 142189.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 214.3 | |
| All* | Total formula weight | 142403.7 |
