7F3O
Crystal structure of the GluA2o LBD in complex with glutamate and TAK-653
Summary for 7F3O
Entry DOI | 10.2210/pdb7f3o/pdb |
Descriptor | Glutamate receptor 2, GLUTAMIC ACID, 7-(4-cyclohexyloxyphenyl)-9-methyl-4$l^{6}-thia-1$l^{4},5,8-triazabicyclo[4.4.0]deca-1(10),6,8-triene 4,4-dioxide, ... (7 entities in total) |
Functional Keywords | ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 179104.62 |
Authors | Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2021-06-16, release date: 2021-07-28, Last modification date: 2023-11-29) |
Primary citation | Suzuki, A.,Kunugi, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Toyofuku, M.,Kuno, H.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement. Sci Rep, 11:14532-14532, 2021 Cited by PubMed: 34267258DOI: 10.1038/s41598-021-93888-0 PDB entries with the same primary citation |
Experimental method |
Structure validation
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