6ZG9

Structure of M1-StaR-T4L in complex with GSK1034702 at 2.5A

Summary for 6ZG9

• Entry DOI: 10.2210/pdb6zg9/pdb
• Descriptor: Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, 7-fluoranyl-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1~{H}-benzimidazol-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: gpcr, 7tm, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 54194.86

Authors

Rucktooa, P.,Cooke, R.M. (deposition date: 2020-06-18, release date: 2021-10-06, Last modification date: 2024-01-24)

• Primary citation: Brown, A.J.H.,Bradley, S.J.,Marshall, F.H.,Brown, G.A.,Bennett, K.A.,Brown, J.,Cansfield, J.E.,Cross, D.M.,de Graaf, C.,Hudson, B.D.,Dwomoh, L.,Dias, J.M.,Errey, J.C.,Hurrell, E.,Liptrot, J.,Mattedi, G.,Molloy, C.,Nathan, P.J.,Okrasa, K.,Osborne, G.,Patel, J.C.,Pickworth, M.,Robertson, N.,Shahabi, S.,Bundgaard, C.,Phillips, K.,Broad, L.M.,Goonawardena, A.V.,Morairty, S.R.,Browning, M.,Perini, F.,Dawson, G.R.,Deakin, J.F.W.,Smith, R.T.,Sexton, P.M.,Warneck, J.,Vinson, M.,Tasker, T.,Tehan, B.G.,Teobald, B.,Christopoulos, A.,Langmead, C.J.,Jazayeri, A.,Cooke, R.M.,Rucktooa, P.,Congreve, M.S.,Weir, M.,Tobin, A.B.; From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.; Cell, 184:5886-, 2021; PubMed: 34822784; DOI: 10.1016/j.cell.2021.11.001

Experimental method

X-RAY DIFFRACTION (2.5 Å)