Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ZG9

Structure of M1-StaR-T4L in complex with GSK1034702 at 2.5A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue QK2 A 1201

Chain	Residue
A	TYR82
A	TYR408
A	HOH1313
A	TYR85
A	TRP91
A	LEU102
A	ASP105
A	SER109
A	CYS178
A	TRP378
A	TYR404

site_id	AC2
Number of Residues	9
Details	binding site for residue EPE A 1202

Chain	Residue
A	TYR179
A	LEU183
A	PRO186
A	THR189
A	SER388
A	GLU397
A	TYR404
A	HOH1304
A	HOH1307

site_id	AC3
Number of Residues	7
Details	binding site for residue OLA A 1203

Chain	Residue
A	GLN57
A	PHE65
A	ILE73
A	LEU143
A	ILE146
A	TRP150
A	OLA1204

site_id	AC4
Number of Residues	9
Details	binding site for residue OLA A 1204

Chain	Residue
A	LEU104
A	VAL107
A	LEU143
A	ILE146
A	GLY147
A	PHE154
A	CYS394
A	OLA1203
A	OLA1207

site_id	AC5
Number of Residues	4
Details	binding site for residue OLA A 1205

Chain	Residue
A	GLU24
A	GLU401
A	TRP405
A	OLA1208

site_id	AC6
Number of Residues	11
Details	binding site for residue OLA A 1206

Chain	Residue
A	LEU93
A	GLY94
A	ALA95
A	LEU96
A	ALA97
A	ALA175
A	CYS205
A	TYR208
A	TRP209
A	TYR212
A	OLA1207

site_id	AC7
Number of Residues	8
Details	binding site for residue OLA A 1207

Chain	Residue
A	HIS90
A	TRP91
A	ALA92
A	LEU93
A	ALA97
A	LEU100
A	OLA1204
A	OLA1206

site_id	AC8
Number of Residues	3
Details	binding site for residue OLA A 1208

Chain	Residue
A	LEU144
A	THR398
A	OLA1205

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 A 1209

Chain	Residue
A	ARG129
A	LEU131
A	SER132
A	ASP1072

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. AAVmNLLLISFDRYFsV

Chain	Residue	Details
A	ALA111-VAL127

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	33
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	36
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	41
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	9
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	15
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Site: {"description":"Subtype-specific residue that binds to snake venom muscarinic toxin 7","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Site: {"description":"Binds to snake venom muscarinic toxin 7","evidences":[{"source":"PubMed","id":"32646996","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P12657","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)