6ZG9
Structure of M1-StaR-T4L in complex with GSK1034702 at 2.5A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1 | polymer | 455 | 51833.4 | 1 | UniProt (P11229) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) | Homo sapiens (Human) | Lysis protein,Lysozyme,Muramidase |
| 2 | B (A) | 7-fluoranyl-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1~{H}-benzimidazol-2-one | non-polymer | 333.4 | 1 | Chemie (QK2) | |||
| 3 | C (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | D, E, F, G, H... (A) | OLEIC ACID | non-polymer | 282.5 | 6 | Chemie (OLA) | |||
| 5 | J (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | K (A) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 27 - 219 (UniProt: P11229)
A: 1002 - 1161 (UniProt: P00720)
A: 354 - 438 (UniProt: P11229)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
| Glu 21 | - | expression tag |
| Thr 22 | - | expression tag |
| Val 23 | - | expression tag |
| Glu 24 | - | expression tag |
| Met 25 | - | expression tag |
| Val 26 | - | expression tag |
| Ala 27 | Phe 27 | engineered mutation |
| Ala 29 | Gly 29 | conflict |
| Thr 30 | Ile 30 | conflict |
| Val 31 | Thr 31 | conflict |
| Ala 32 | Thr 32 | engineered mutation |
| Ile 44 | Leu 44 | engineered mutation |
| Leu 46 | Val 46 | engineered mutation |
| Met 47 | Leu 47 | conflict |
| Leu 48 | Ile 48 | conflict |
| Ile 50 | Phe 50 | conflict |
| Arg 54 | Thr 54 | conflict |
| Gln 55 | Glu 55 | conflict |
| Gln 57 | Lys 57 | conflict |
| Ala 64 | Leu 64 | engineered mutation |
| Phe 65 | Leu 65 | conflict |
| Ala 76 | Thr 76 | engineered mutation |
| Val 84 | Thr 84 | engineered mutation |
| Ile 86 | Leu 86 | conflict |
| Ile 87 | Leu 87 | conflict |
| Ala 95 | Thr 95 | engineered mutation |
| Ala 101 | Trp 101 | engineered mutation |
| Ala 112 | Ser 112 | engineered mutation |
| Leu 143 | Ala 143 | engineered mutation |
| Thr 196 | Ala 196 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 1012 | Arg 12 | conflict |
| Thr 1054 | Cys 54 | conflict |
| Ala 1097 | Cys 97 | conflict |
| Arg 1137 | Ile 137 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 362 | Lys 362 | engineered mutation |
| Leu 364 | Ala 364 | engineered mutation |
| Ala 411 | Ser 411 | engineered mutation |
| Ala 435 | Cys 435 | conflict |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
| His 441 | - | expression tag |
| His 442 | - | expression tag |
| His 443 | - | expression tag |
| His 444 | - | expression tag |
| His 445 | - | expression tag |
| His 446 | - | expression tag |
| His 447 | - | expression tag |
| His 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51833.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2361.4 | |
| All* | Total formula weight | 54194.9 |
