6ZC8

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

Summary for 6ZC8

Entry DOI	10.2210/pdb6zc8/pdb
Descriptor	Segment polarity protein dishevelled homolog DVL-3, 2-[[3-chloranyl-4-[(1~{H}-indazol-3-ylcarbonylamino)methyl]phenyl]sulfonylamino]-5-methyl-benzoic acid (3 entities in total)
Functional Keywords	pdz, dvl, inhibitors, wnt, signalling, peptide binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	21397.24
Authors	Roske, Y.,Heinemann, U.,Oschkinat, H. (deposition date: 2020-06-10, release date: 2021-06-23, Last modification date: 2024-01-24)
Primary citation	Roske, Y.,Heinemann, U.,Oschkinat, H.,Kamdem, N.,Kovalskyy, D.,Platonov, M.O.,Balinskyi, O.M.,Kreuchwig, A.,Saupe, J.,Fang, L.,Diehl, A.,Schmieder, P.,Krause, G.,Rademann, J.,Birchmeier, W. Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling J.Magn.Reson., 2021 Cited by DOI: 10.5194/mr-2-355-2021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation