6ZC8
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Segment polarity protein dishevelled homolog DVL-3 | polymer | 95 | 10199.7 | 2 | UniProt (Q92997) Pfam (PF00595) | Homo sapiens (Human) | Dishevelled-3,DSH homolog 3 |
| 2 | C, D (A, B) | 2-[[3-chloranyl-4-[(1~{H}-indazol-3-ylcarbonylamino)methyl]phenyl]sulfonylamino]-5-methyl-benzoic acid | non-polymer | 498.9 | 2 | Chemie (QEK) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A, B: 243 - 335 (UniProt: Q92997)
| PDB | External Database | Details |
|---|---|---|
| Ala 242 | - | expression tag |
| Ser 336 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20399.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 997.9 | |
| All* | Total formula weight | 21397.2 |
