6Z8V

X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3L), which contains 1-beta-D-lactopyranosyl residue in the side chain of Thy3 at N3.

6Z8V の概要

• エントリーDOI: 10.2210/pdb6z8v/pdb
• 関連するPDBエントリー: 6Z8W 6Z8X
• 分子名称: Prothrombin, TBA-3L, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (7 entities in total)
• 機能のキーワード: modified aptamer, dna-protein complex, anticoaugulant, g-quadruplex, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 39216.95

構造登録者

Troisi, R.,Timofeev, E.N.,Sica, F. (登録日: 2020-06-02, 公開日: 2021-01-27, 最終更新日: 2024-01-24)

• 主引用文献: Smirnov, I.,Kolganova, N.,Troisi, R.,Sica, F.,Timofeev, E.; Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.; Mol Ther Nucleic Acids, 23:863-871, 2021; PubMed: 33614235; DOI: 10.1016/j.omtn.2021.01.004

実験手法

X-RAY DIFFRACTION (1.58 Å)