6Z8V

X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3L), which contains 1-beta-D-lactopyranosyl residue in the side chain of Thy3 at N3.

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue 0G6 H 301

Chain	Residue
H	HIS57
H	SER214
H	TRP215
H	GLY216
H	GLY219
H	GLY226
H	HOH410
H	HOH445
H	HOH473
H	HOH481
H	HOH497
H	TYR60
H	TRP60
H	GLU97
H	LEU99
H	ASP189
H	ALA190
H	GLY193
H	SER195

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site_id	AC2
Number of Residues	6
Details	binding site for residue NA H 302

Chain	Residue
H	ARG221
H	LYS224
H	HOH433
H	HOH435
H	HOH447
H	HOH520

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site_id	AC3
Number of Residues	8
Details	binding site for residue K A 101

Chain	Residue
A	DG1
A	DG2
A	DG5
A	DG6
A	DG10
A	DG11
A	DG14
A	DG15

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site_id	AC4
Number of Residues	4
Details	binding site for residue QCK A 3

Chain	Residue
A	DG2
A	DT4
H	TYR76
H	ILE82

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923

Chain	Residue	Details
H	ASN60

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