6YG1

Crystal structure of MKK7 (MAP2K7) in an active state, allosterically triggered by the N-terminal helix

Summary for 6YG1

Entry DOI	10.2210/pdb6yg1/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 7, SODIUM ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	kinase, kinase inhibitor, mkk7, mek7, map2k7, map2k, mek, jnk signaling, structural genomics, structural genomics consortium, sgc, transferase, scottish structural proteomics facility, sspf
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	120409.38
Authors	Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC),Scottish Structural Proteomics Facility (SSPF) (deposition date: 2020-03-27, release date: 2020-08-12, Last modification date: 2024-01-24)
Primary citation	Schroder, M.,Tan, L.,Wang, J.,Liang, Y.,Gray, N.S.,Knapp, S.,Chaikuad, A. Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol, 27:1285-1295.e4, 2020 Cited by PubMed: 32783966 DOI: 10.1016/j.chembiol.2020.07.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation