6YG1
Crystal structure of MKK7 (MAP2K7) in an active state, allosterically triggered by the N-terminal helix
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Dual specificity mitogen-activated protein kinase kinase 7 | polymer | 348 | 39630.0 | 3 | UniProt (O14733) Pfam (PF00069) | Homo sapiens (Human) | MAPKK 7,JNK-activating kinase 2,MAPK/ERK kinase 7,MEK 7,Stress-activated protein kinase kinase 4,SAPKK4,c-Jun N-terminal kinase kinase 2,JNKK 2 |
| 2 | BA, CA, D, V (C, A, B) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 3 | AA, DA, E, F, G... (B, C, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 23 | Chemie (EDO) | |||
| 4 | EA, FA, GA (A, B, C) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A, B, C: 76 - 421 (UniProt: O14733)
| PDB | External Database | Details |
|---|---|---|
| Ser 74 | - | expression tag |
| Met 75 | - | expression tag |
| Asp 287 | Ser 271 | engineered mutation |
| Asp 291 | Thr 275 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118889.9 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 1519.5 | |
| All* | Total formula weight | 120409.4 |
