6YG1

Crystal structure of MKK7 (MAP2K7) in an active state, allosterically triggered by the N-terminal helix

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 501

Chain	Residue
A	SER189
A	HIS190
A	CYS192
A	ILE195
A	GLN197
A	HOH647

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 502

Chain	Residue
A	VAL161
A	GLU213
A	LEU214

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 503

Chain	Residue
A	ILE115
A	GLN118
A	LEU187
A	THR201
A	HOH707

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 504

Chain	Residue
A	TYR121
A	ARG128
A	HOH674
B	PHE345
C	GLN353

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 505

Chain	Residue
A	TYR247
A	LYS250
A	LYS386
A	TYR387
A	ASN388

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 506

Chain	Residue
A	LYS383
A	PRO385
A	LYS386
A	LYS389

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 507

Chain	Residue
A	TYR129
A	THR158
A	GLU232
A	ARG398
A	TYR399

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 508

Chain	Residue
A	GLN227
A	THR333
B	ASN340

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 509

Chain	Residue
A	ILE280
A	ASP291
A	SER293
A	ALA294

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 510

Chain	Residue
A	TYR299
A	GLU330
A	HOH677

---

site_id	AD2
Number of Residues	1
Details	binding site for residue EDO A 511

Chain	Residue
A	CYS341

---

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 512

Chain	Residue
A	ASP344
A	ASP344
A	PHE345
A	LEU348
A	LEU348
A	HOH630
A	HOH630

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 513

Chain	Residue
A	PRO302
A	ASP306
A	LYS379

---

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO A 514

Chain	Residue
A	ASP306
A	PRO307

---

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO A 515

Chain	Residue
A	PRO337
A	TYR338
A	ASN340
A	CYS341
B	MET363

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 516

Chain	Residue
A	GLU354
A	HOH656
B	GLY364

---

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO A 517

Chain	Residue
A	ASN176
A	HOH624

---

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO A 518

Chain	Residue
A	ASP306
A	THR349
A	HOH622
A	HOH634
A	HOH700

---

site_id	AE1
Number of Residues	5
Details	binding site for residue NA B 501

Chain	Residue
B	SER189
B	HIS190
B	CYS192
B	ILE195
B	GLN197

---

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO B 502

Chain	Residue
A	GLY126
B	THR349
B	LYS350
B	GLU354

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO B 503

Chain	Residue
B	TYR299
B	GLU330
B	HOH641

---

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO B 504

Chain	Residue
A	PRO310
A	LYS342
B	ARG233

---

site_id	AE5
Number of Residues	5
Details	binding site for residue EDO B 505

Chain	Residue
B	ARG270
B	VAL404
B	ASP405
B	VAL406
B	ALA407

---

site_id	AE6
Number of Residues	6
Details	binding site for residue EDO B 506

Chain	Residue
B	ALA297
B	ASP344
B	LEU348
C	ASP344
C	PHE345
C	LEU348

---

site_id	AE7
Number of Residues	5
Details	binding site for residue NA C 501

Chain	Residue
C	CYS192
C	ILE195
C	GLN197
C	SER189
C	HIS190

---

site_id	AE8
Number of Residues	7
Details	binding site for residue NA C 502

Chain	Residue
C	ARG225
C	MET414
C	MET414
C	ALA415
C	ALA415
C	THR417
C	THR417

---

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO C 503

Chain	Residue
C	LYS250
C	TYR387
C	ASN388

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNILL

Chain	Residue	Details
A	VAL255-LEU267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	69
Details	Region: {"description":"DVD domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by MAP3K","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine; by MAP3K","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---