6Y8O

Mycobacterium smegmatis GyrB 22kDa ATPase sub-domain in complex with novobiocin

6Y8O の概要

• エントリーDOI: 10.2210/pdb6y8o/pdb
• 関連するPDBエントリー: 6Y8L 6Y8N
• 分子名称: DNA gyrase subunit B, NOVOBIOCIN, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: binding sites, dna gyrase, inhibitors, , novobiocin iv, isomerase, dna binding protein
• 由来する生物種: Mycolicibacterium smegmatis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54442.51

構造登録者

Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.,Lawson, D.M.,Maxwell, A. (登録日: 2020-03-05, 公開日: 2020-08-12, 最終更新日: 2024-01-24)

主引用文献

Henderson, S.R.,Stevenson, C.E.M.,Malone, B.,Zholnerovych, Y.,Mitchenall, L.A.,Pichowicz, M.,McGarry, D.H.,Cooper, I.R.,Charrier, C.,Salisbury, A.M.,Lawson, D.M.,Maxwell, A.
Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
J.Antimicrob.Chemother., 75:2835-2842, 2020

PubMed Abstract: To evaluate the efficacy of two novel compounds against mycobacteria and determine the molecular basis of their action on DNA gyrase using structural and mechanistic approaches.

PubMed: 32728686
DOI: 10.1093/jac/dkaa286

実験手法

X-RAY DIFFRACTION (1.6 Å)