6WVZ

Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET

Summary for 6WVZ

• Entry DOI: 10.2210/pdb6wvz/pdb
• Descriptor: Heavy Chain of anti-MET Fab of amivantamab, Light Chain of anti-MET Fab of amivantamab, Hepatocyte growth factor receptor, ... (8 entities in total)
• Functional Keywords: antigen-fab complex, semaphorin domain, plexin semaphorin integrin cysteine-rich domain, antitumor protein, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 110928.31

Authors

Cardoso, R.M.F. (deposition date: 2020-05-07, release date: 2021-04-28, Last modification date: 2023-10-18)

• Primary citation: Neijssen, J.,Cardoso, R.M.F.,Chevalier, K.M.,Wiegman, L.,Valerius, T.,Anderson, G.M.,Moores, S.L.,Schuurman, J.,Parren, P.W.H.I.,Strohl, W.R.,Chiu, M.L.; Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.; J.Biol.Chem., 296:100641-100641, 2021; PubMed: 33839159; DOI: 10.1016/j.jbc.2021.100641

Experimental method

X-RAY DIFFRACTION (3.1 Å)