6WVZ
Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H | Heavy Chain of anti-MET Fab of amivantamab | polymer | 228 | 24647.4 | 1 | Homo sapiens | ||
2 | L | Light Chain of anti-MET Fab of amivantamab | polymer | 214 | 23264.9 | 1 | Homo sapiens | ||
3 | M | Hepatocyte growth factor receptor | polymer | 534 | 60758.9 | 1 | UniProt (P08581) Pfam (PF01403) Pfam (PF01437) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
4 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | B, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
6 | M | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
7 | M | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
8 | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
M: 39 - 564 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
His 565 | - | expression tag |
His 566 | - | expression tag |
His 567 | - | expression tag |
His 568 | - | expression tag |
His 569 | - | expression tag |
His 570 | - | expression tag |
His 571 | - | expression tag |
His 572 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 108671.2 | |
Branched | Number of molecules | 4 |
Total formula weight | 1989.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 267.2 | |
All* | Total formula weight | 110928.3 |