6WVZ

Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Heavy Chain of anti-MET Fab of amivantamab	polymer	228	24647.4	1		Homo sapiens
2	B (L)	Light Chain of anti-MET Fab of amivantamab	polymer	214	23264.9	1		Homo sapiens
3	C (M)	Hepatocyte growth factor receptor	polymer	534	60758.9	1	UniProt (P08581) Pfam (PF01403) Pfam (PF01437)	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
4	D, F (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	E, G (B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
6	H (M)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	I (M)	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
8	J, K, L (H, L, M)	water	water		18.0	52	Chemie (HOH)

Sequence modifications

M: 39 - 564 (UniProt: P08581)

PDB	External Database	Details
His 565	-	expression tag
His 566	-	expression tag
His 567	-	expression tag
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag
His 571	-	expression tag
His 572	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	108671.2
Branched	Number of molecules	4
	Total formula weight	1989.9
Non-Polymers*	Number of molecules	2
	Total formula weight	267.2
All*	Total formula weight	110928.3

*Water molecules are not included.