6WCD
Crystal Structure of Xenopus laevis APE2 Catalytic Domain
Summary for 6WCD
Entry DOI | 10.2210/pdb6wcd/pdb |
Related | 5U6Z |
Descriptor | DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total) |
Functional Keywords | nuclease, dna repair, hydrolase |
Biological source | Xenopus laevis (African clawed frog) |
Total number of polymer chains | 1 |
Total formula weight | 40407.58 |
Authors | Wojtaszek, J.L.,Wallace, B.D.,Williams, R.S. (deposition date: 2020-03-30, release date: 2020-05-06, Last modification date: 2023-10-18) |
Primary citation | Alvarez-Quilon, A.,Wojtaszek, J.L.,Mathieu, M.C.,Patel, T.,Appel, C.D.,Hustedt, N.,Rossi, S.E.,Wallace, B.D.,Setiaputra, D.,Adam, S.,Ohashi, Y.,Melo, H.,Cho, T.,Gervais, C.,Munoz, I.M.,Grazzini, E.,Young, J.T.F.,Rouse, J.,Zinda, M.,Williams, R.S.,Durocher, D. Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Mol.Cell, 78:1152-, 2020 Cited by PubMed: 32516598DOI: 10.1016/j.molcel.2020.05.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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