6V14

Crystal structure of the bromodomain of human BRD9 bound to TP472

Summary for 6V14

Entry DOI	10.2210/pdb6v14/pdb
Descriptor	Bromodomain-containing protein 9, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	brd9, mswi/snf, baf, non-bet, brd, tp472, tp-472, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14645.22
Authors	Karim, M.R.,Chan, A.,Schonbrunn, E. (deposition date: 2019-11-19, release date: 2020-03-11, Last modification date: 2023-10-11)
Primary citation	Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63:3227-3237, 2020 Cited by PubMed: 32091206 DOI: 10.1021/acs.jmedchem.9b01980 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation