6UZA
Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473
Summary for 6UZA
Entry DOI | 10.2210/pdb6uza/pdb |
Related | 6UZ8 |
EMDB information | 20953 20954 |
Descriptor | Short transient receptor potential channel 6, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, ... (5 entities in total) |
Functional Keywords | trp channel, antagonist, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 398056.10 |
Authors | |
Primary citation | Bai, Y.,Yu, X.,Chen, H.,Horne, D.,White, R.,Wu, X.,Lee, P.,Gu, Y.,Ghimire-Rijal, S.,Lin, D.C.,Huang, X. Structural basis for pharmacological modulation of the TRPC6 channel. Elife, 9:-, 2020 Cited by PubMed: 32149605DOI: 10.7554/eLife.53311 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.08 Å) |
Structure validation
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