6UQB

Crystal structure of R471A variant of cytosolic fumarate hydratase from Leishmania major in a complex with S-malate and malonate

6UQB の概要

• エントリーDOI: 10.2210/pdb6uqb/pdb
• 関連するPDBエントリー: 6UNZ 6UO0 6UOI 6UOJ 6UP9 6UPM 6UPO 6UQ8 6UQ9 6UQL 6UQM 6UQN
• 分子名称: Fumarate hydratase 2, IRON/SULFUR CLUSTER, (2S)-2-hydroxybutanedioic acid, ... (6 entities in total)
• 機能のキーワード: fumarate hydratase, fumarase, leishmania major, variant h334a, substrate, s-malate, inhibitor, malonate, lyase
• 由来する生物種: Leishmania major strain Friedlin
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 134426.59

構造登録者

Feliciano, P.R.,Drennan, C.L. (登録日: 2019-10-18, 公開日: 2019-12-04, 最終更新日: 2023-10-11)

• 主引用文献: Feliciano, P.R.,Drennan, C.L.; Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major.; Biochemistry, 58:5011-5021, 2019; PubMed: 31743022; DOI: 10.1021/acs.biochem.9b00923

実験手法

X-RAY DIFFRACTION (1.951 Å)