6UQ8

Crystal structure of R421A variant of cytosolic fumarate hydratase from Leishmania major in a complex with S-malate and malonate

Summary for 6UQ8

Entry DOI	10.2210/pdb6uq8/pdb
Related	6UNZ 6UO0 6UOI 6UOJ 6UP9 6UPM 6UPO 6UQ9 6UQB 6UQL 6UQM 6UQN
Descriptor	Fumarate hydratase 2, IRON/SULFUR CLUSTER, (2S)-2-hydroxybutanedioic acid, ... (6 entities in total)
Functional Keywords	fumarate hydratase, fumarase, leishmania major, variant r421a, substrate, s-malate, inhibitor, malonate, lyase
Biological source	Leishmania major strain Friedlin
Total number of polymer chains	2
Total formula weight	134702.87
Authors	Feliciano, P.R.,Drennan, C.L. (deposition date: 2019-10-18, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citation	Feliciano, P.R.,Drennan, C.L. Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major. Biochemistry, 58:5011-5021, 2019 Cited by PubMed: 31743022 DOI: 10.1021/acs.biochem.9b00923 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.339 Å)

Structure validation