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6UQB

Crystal structure of R471A variant of cytosolic fumarate hydratase from Leishmania major in a complex with S-malate and malonate

Summary for 6UQB
Entry DOI10.2210/pdb6uqb/pdb
Related6UNZ 6UO0 6UOI 6UOJ 6UP9 6UPM 6UPO 6UQ8 6UQ9 6UQL 6UQM 6UQN
DescriptorFumarate hydratase 2, IRON/SULFUR CLUSTER, (2S)-2-hydroxybutanedioic acid, ... (6 entities in total)
Functional Keywordsfumarate hydratase, fumarase, leishmania major, variant h334a, substrate, s-malate, inhibitor, malonate, lyase
Biological sourceLeishmania major strain Friedlin
Total number of polymer chains2
Total formula weight134426.59
Authors
Feliciano, P.R.,Drennan, C.L. (deposition date: 2019-10-18, release date: 2019-12-04, Last modification date: 2023-10-11)
Primary citationFeliciano, P.R.,Drennan, C.L.
Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major.
Biochemistry, 58:5011-5021, 2019
Cited by
PubMed: 31743022
DOI: 10.1021/acs.biochem.9b00923
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.951 Å)
Structure validation

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