6U2G
BRAF-MEK complex with AMP-PCP bound to BRAF
Summary for 6U2G
| Entry DOI | 10.2210/pdb6u2g/pdb |
| Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, Serine/threonine-protein kinase B-raf, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (6 entities in total) |
| Functional Keywords | kinase, amp-pcp, dimer, signaling protei, transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 79879.59 |
| Authors | Liau, N.P.D.,Wendorff, T.,Hymowitz, S.,Sudhamsu, J. (deposition date: 2019-08-19, release date: 2019-08-28, Last modification date: 2023-10-11) |
| Primary citation | Liau, N.P.D.,Wendorff, T.J.,Quinn, J.G.,Steffek, M.,Phung, W.,Liu, P.,Tang, J.,Irudayanathan, F.J.,Izadi, S.,Shaw, A.S.,Malek, S.,Hymowitz, S.G.,Sudhamsu, J. Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nat.Struct.Mol.Biol., 27:134-141, 2020 Cited by PubMed: 31988522DOI: 10.1038/s41594-019-0365-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.886 Å) |
Structure validation
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