6U2G

BRAF-MEK complex with AMP-PCP bound to BRAF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dual specificity mitogen-activated protein kinase kinase 1	polymer	394	43506.9	1	UniProt (Q02750) Pfam (PF00069)	Homo sapiens (Human)	MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1
2	B (B)	Serine/threonine-protein kinase B-raf	polymer	307	35217.6	1	UniProt (P15056) Pfam (PF07714)	Homo sapiens (Human)	Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
3	C, G (A, B)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	2	Chemie (ACP)
4	D, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	E (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	H, I (A, B)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 2 - 393 (UniProt: Q02750)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 1	-	expression tag

B: 432 - 726 (UniProt: P15056)

PDB	External Database	Details
Met 420	-	expression tag
Asp 421	-	expression tag
Arg 422	-	expression tag
Gly 423	-	expression tag
Ser 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
Gly 431	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78724.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1155.1
All*	Total formula weight	79879.6

*Water molecules are not included.