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6U2G

BRAF-MEK complex with AMP-PCP bound to BRAF

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000187biological_processobsolete activation of MAPK activity
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005078molecular_functionMAP-kinase scaffold activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006935biological_processchemotaxis
A0007165biological_processsignal transduction
A0007254biological_processJNK cascade
A0007507biological_processheart development
A0008285biological_processnegative regulation of cell population proliferation
A0008545molecular_functionJUN kinase kinase activity
A0010628biological_processpositive regulation of gene expression
A0014044biological_processSchwann cell development
A0016020cellular_componentmembrane
A0021697biological_processcerebellar cortex formation
A0030182biological_processneuron differentiation
A0030216biological_processkeratinocyte differentiation
A0030295molecular_functionprotein kinase activator activity
A0030878biological_processthyroid gland development
A0032872biological_processregulation of stress-activated MAPK cascade
A0035401molecular_functionhistone H3Y41 kinase activity
A0035987biological_processendodermal cell differentiation
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042552biological_processmyelination
A0043410biological_processpositive regulation of MAPK cascade
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044342biological_processtype B pancreatic cell proliferation
A0045893biological_processpositive regulation of DNA-templated transcription
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048538biological_processthymus development
A0048679biological_processregulation of axon regeneration
A0048870biological_processcell motility
A0050772biological_processpositive regulation of axonogenesis
A0060020biological_processBergmann glial cell differentiation
A0060324biological_processface development
A0060425biological_processlung morphogenesis
A0060440biological_processtrachea formation
A0060502biological_processepithelial cell proliferation involved in lung morphogenesis
A0060674biological_processplacenta blood vessel development
A0060711biological_processlabyrinthine layer development
A0070371biological_processERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090170biological_processregulation of Golgi inheritance
A0090398biological_processcellular senescence
A0097110molecular_functionscaffold protein binding
A0106310molecular_functionprotein serine kinase activity
A0140801molecular_functionhistone H2AXY142 kinase activity
A1903226biological_processpositive regulation of endodermal cell differentiation
A2000641biological_processregulation of early endosome to late endosome transport
B0004672molecular_functionprotein kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue ACP A 901
ChainResidue
ALEU74
ASER150
AGLN153
ALYS192
ASER194
ALEU197
AASP208
AMG902
AHOH1006
AHOH1007
AHOH1017
AGLY77
AASN78
AVAL82
AALA95
ALYS97
AMET143
AGLU144
AMET146

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 902
ChainResidue
AASN195
AASP208
AACP901
AHOH1006
AHOH1007

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 903
ChainResidue
AARG189
AARG234
AHIS239

site_idAC4
Number of Residues4
Detailsbinding site for residue MG B 900
ChainResidue
BASN581
BASP594
BACP901
BHOH1009

site_idAC5
Number of Residues22
Detailsbinding site for residue ACP B 901
ChainResidue
AGLU102
ALEU381
BILE463
BGLY464
BGLY466
BSER467
BGLY469
BVAL471
BALA481
BLYS483
BGLN530
BTRP531
BCYS532
BASP576
BLYS578
BASN580
BASN581
BPHE583
BASP594
BMG900
BHOH1006
BHOH1009

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues21
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK
ChainResidueDetails
BILE463-LYS483
ALEU74-LYS97

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL
ChainResidueDetails
BILE572-LEU584
AILE186-VAL198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
BASP576

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BILE463
BLYS483
ASER150
ALYS192
AASP208

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Breakpoint for translocation to form KIAA1549-BRAF fusion protein
ChainResidueDetails
BMET438

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER446
ASER194

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER447

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714
ChainResidueDetails
BARG671

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581
ChainResidueDetails
BLYS578

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
ATHR286

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAPK1 => ECO:0000250|UniProtKB:Q01986
ChainResidueDetails
ATHR292

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PAK => ECO:0000269|PubMed:16129686
ChainResidueDetails
ASER298

227111

PDB entries from 2024-11-06

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