6QMR

Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid

Summary for 6QMR

Entry DOI	10.2210/pdb6qmr/pdb
Descriptor	Complement factor D, 2-[2-[[3-[3-[(1~{S})-1-azanyl-2-oxidanyl-ethyl]phenyl]phenyl]methoxy]phenyl]ethanoic acid (3 entities in total)
Functional Keywords	complement factor d, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	164852.21
Authors	Karki, R.,Powers, J.,Mainolfi, N.,Anderson, K.,Belanger, D.,Liu, D.,Jendza, K.,Gelin, C.F.,Solovay, C.,Mac Sweeeny, A.,Delgado, O.,Crowley, M.,Liao, S.-M.,Argikar, U.A.,Flohr, S.,La Bonte, L.R.,Lorthiois, E.L.,Vulpetti, A.,Cumin, F.,Brown, A.,Adams, C.,Jaffee, B.,Mogi, M. (deposition date: 2019-02-08, release date: 2019-04-24, Last modification date: 2024-01-24)
Primary citation	Karki, R.G.,Powers, J.,Mainolfi, N.,Anderson, K.,Belanger, D.B.,Liu, D.,Ji, N.,Jendza, K.,Gelin, C.F.,Mac Sweeney, A.,Solovay, C.,Delgado, O.,Crowley, M.,Liao, S.M.,Argikar, U.A.,Flohr, S.,La Bonte, L.R.,Lorthiois, E.L.,Vulpetti, A.,Brown, A.,Long, D.,Prentiss, M.,Gradoux, N.,de Erkenez, A.,Cumin, F.,Adams, C.,Jaffee, B.,Mogi, M. Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway. J.Med.Chem., 62:4656-4668, 2019 Cited by PubMed: 30995036 DOI: 10.1021/acs.jmedchem.9b00271 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation