6QMR
Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Complement factor D | polymer | 254 | 27097.9 | 6 | UniProt (P00746) Pfam (PF00089) | Homo sapiens (Human) | Adipsin,C3 convertase activator,Properdin factor D |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 2-[2-[[3-[3-[(1~{S})-1-azanyl-2-oxidanyl-ethyl]phenyl]phenyl]methoxy]phenyl]ethanoic acid | non-polymer | 377.4 | 6 | Chemie (J6T) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 320 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: -8 - 243 (UniProt: P00746)
| PDB | External Database | Details |
|---|---|---|
| Ser 244 | - | expression tag |
| Ala 245 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 162587.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2264.6 | |
| All* | Total formula weight | 164852.2 |
