6QMR

Complement factor D in complex with the inhibitor (S)-2-(2-((3'-(1-amino-2-hydroxyethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)acetic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue J6T A 301

Chain	Residue
A	LEU41
A	THR214
A	SER215
A	ARG218
A	VAL219
A	GLY226
A	ILE227
A	HOH401
D	ASP61
A	HIS57
A	ASP189
A	SER190
A	CYS191
A	LYS192
A	GLY193
A	ASP194
A	SER195

---

site_id	AC2
Number of Residues	18
Details	binding site for residue J6T B 301

Chain	Residue
B	LEU41
B	CYS42
B	HIS57
B	ASP189
B	SER190
B	CYS191
B	LYS192
B	GLY193
B	ASP194
B	SER195
B	THR214
B	SER215
B	ARG218
B	VAL219
B	CYS220
B	GLY226
B	ILE227
B	HOH406

---

site_id	AC3
Number of Residues	19
Details	binding site for residue J6T C 301

Chain	Residue
B	ASP61
C	LEU41
C	HIS57
C	ASP189
C	SER190
C	CYS191
C	LYS192
C	GLY193
C	ASP194
C	SER195
C	VAL213
C	THR214
C	SER215
C	ARG218
C	VAL219
C	CYS220
C	GLY226
C	ILE227
C	HOH428

---

site_id	AC4
Number of Residues	17
Details	binding site for residue J6T D 301

Chain	Residue
D	LEU41
D	CYS42
D	HIS57
D	ASP189
D	SER190
D	CYS191
D	LYS192
D	GLY193
D	ASP194
D	SER195
D	THR214
D	SER215
D	ARG218
D	CYS220
D	GLY226
D	ILE227
D	HOH406

---

site_id	AC5
Number of Residues	17
Details	binding site for residue J6T E 301

Chain	Residue
E	HIS57
E	ASP189
E	SER190
E	CYS191
E	LYS192
E	GLY193
E	ASP194
E	SER195
E	VAL213
E	THR214
E	SER215
E	ARG218
E	VAL219
E	CYS220
E	GLY226
E	ILE227
E	HOH409

---

site_id	AC6
Number of Residues	17
Details	binding site for residue J6T F 301

Chain	Residue
F	ARG218
F	VAL219
F	CYS220
F	GLY226
F	ILE227
F	HOH401
F	HIS57
F	ASP189
F	SER190
F	CYS191
F	LYS192
F	GLY193
F	ASP194
F	SER195
F	VAL213
F	THR214
F	SER215

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1135
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"Self-inhibitor loop","evidences":[{"source":"PubMed","id":"10022823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9753554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"7592653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21205667","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22362762","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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