6P8H
Crystal structure of CDK4 in complex with CyclinD1 and P21
Summary for 6P8H
Entry DOI | 10.2210/pdb6p8h/pdb |
Descriptor | G1/S-specific cyclin-D1, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1 (3 entities in total) |
Functional Keywords | cyclin-dependent kinase, kinase inhibitor, cell cycle, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 71480.49 |
Authors | Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Bunch, K.,Tripathi, S.M.,Shokat, K.M.,Rubin, S.M. (deposition date: 2019-06-07, release date: 2019-12-25, Last modification date: 2023-10-11) |
Primary citation | Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Kumarasamy, V.,Wijeratne, T.U.,Bunch, K.L.,Tripathi, S.,Knudsen, E.S.,Witkiewicz, A.K.,Shokat, K.M.,Rubin, S.M. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science, 366:-, 2019 Cited by PubMed: 31831640DOI: 10.1126/science.aaw2106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.19 Å) |
Structure validation
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