6OVG
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Summary for 6OVG
Entry DOI | 10.2210/pdb6ovg/pdb |
Descriptor | Cystathionine gamma-lyase, SULFATE ION (3 entities in total) |
Functional Keywords | engineering, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 365920.44 |
Authors | |
Primary citation | Lu, W.C.,Saha, A.,Yan, W.,Garrison, K.,Lamb, C.,Pandey, R.,Irani, S.,Lodi, A.,Lu, X.,Tiziani, S.,Zhang, Y.J.,Georgiou, G.,DiGiovanni, J.,Stone, E. Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity. Proc.Natl.Acad.Sci.USA, 117:13000-13011, 2020 Cited by PubMed: 32434918DOI: 10.1073/pnas.1917362117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.719 Å) |
Structure validation
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