6NQT

GalNac-T2 soaked with UDP-sugar

Summary for 6NQT

• Entry DOI: 10.2210/pdb6nqt/pdb
• Descriptor: Polypeptide N-acetylgalactosaminyltransferase 2, MANGANESE (II) ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R},6~{R})-3-(hex-5-ynoylamino)-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl] hydrogen phosphate, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 392723.57

Authors

Fernandez, D.,Bertozzi, C.R.,Schumann, B.,Agbay, A. (deposition date: 2019-01-21, release date: 2020-01-29, Last modification date: 2023-10-11)

• Primary citation: Schumann, B.,Malaker, S.A.,Wisnovsky, S.P.,Debets, M.F.,Agbay, A.J.,Fernandez, D.,Wagner, L.J.S.,Lin, L.,Li, Z.,Choi, J.,Fox, D.M.,Peh, J.,Gray, M.A.,Pedram, K.,Kohler, J.J.,Mrksich, M.,Bertozzi, C.R.; Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.; Mol.Cell, 78:824-834.e15, 2020; PubMed: 32325029; DOI: 10.1016/j.molcel.2020.03.030

Experimental method

X-RAY DIFFRACTION (3.05 Å)