6NQT

GalNac-T2 soaked with UDP-sugar

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005795	cellular_component	Golgi stack
A	0006486	biological_process	protein glycosylation
A	0006493	biological_process	protein O-linked glycosylation
A	0016020	cellular_component	membrane
A	0016266	biological_process	O-glycan processing
A	0016757	molecular_function	glycosyltransferase activity
A	0018242	biological_process	protein O-linked glycosylation via serine
A	0018243	biological_process	protein O-linked glycosylation via threonine
A	0030145	molecular_function	manganese ion binding
A	0030246	molecular_function	carbohydrate binding
A	0032580	cellular_component	Golgi cisterna membrane
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051604	biological_process	protein maturation
B	0000139	cellular_component	Golgi membrane
B	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005795	cellular_component	Golgi stack
B	0006486	biological_process	protein glycosylation
B	0006493	biological_process	protein O-linked glycosylation
B	0016020	cellular_component	membrane
B	0016266	biological_process	O-glycan processing
B	0016757	molecular_function	glycosyltransferase activity
B	0018242	biological_process	protein O-linked glycosylation via serine
B	0018243	biological_process	protein O-linked glycosylation via threonine
B	0030145	molecular_function	manganese ion binding
B	0030246	molecular_function	carbohydrate binding
B	0032580	cellular_component	Golgi cisterna membrane
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051604	biological_process	protein maturation
C	0000139	cellular_component	Golgi membrane
C	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005795	cellular_component	Golgi stack
C	0006486	biological_process	protein glycosylation
C	0006493	biological_process	protein O-linked glycosylation
C	0016020	cellular_component	membrane
C	0016266	biological_process	O-glycan processing
C	0016757	molecular_function	glycosyltransferase activity
C	0018242	biological_process	protein O-linked glycosylation via serine
C	0018243	biological_process	protein O-linked glycosylation via threonine
C	0030145	molecular_function	manganese ion binding
C	0030246	molecular_function	carbohydrate binding
C	0032580	cellular_component	Golgi cisterna membrane
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051604	biological_process	protein maturation
D	0000139	cellular_component	Golgi membrane
D	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005795	cellular_component	Golgi stack
D	0006486	biological_process	protein glycosylation
D	0006493	biological_process	protein O-linked glycosylation
D	0016020	cellular_component	membrane
D	0016266	biological_process	O-glycan processing
D	0016757	molecular_function	glycosyltransferase activity
D	0018242	biological_process	protein O-linked glycosylation via serine
D	0018243	biological_process	protein O-linked glycosylation via threonine
D	0030145	molecular_function	manganese ion binding
D	0030246	molecular_function	carbohydrate binding
D	0032580	cellular_component	Golgi cisterna membrane
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051604	biological_process	protein maturation
E	0000139	cellular_component	Golgi membrane
E	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005795	cellular_component	Golgi stack
E	0006486	biological_process	protein glycosylation
E	0006493	biological_process	protein O-linked glycosylation
E	0016020	cellular_component	membrane
E	0016266	biological_process	O-glycan processing
E	0016757	molecular_function	glycosyltransferase activity
E	0018242	biological_process	protein O-linked glycosylation via serine
E	0018243	biological_process	protein O-linked glycosylation via threonine
E	0030145	molecular_function	manganese ion binding
E	0030246	molecular_function	carbohydrate binding
E	0032580	cellular_component	Golgi cisterna membrane
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051604	biological_process	protein maturation
F	0000139	cellular_component	Golgi membrane
F	0004653	molecular_function	polypeptide N-acetylgalactosaminyltransferase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005795	cellular_component	Golgi stack
F	0006486	biological_process	protein glycosylation
F	0006493	biological_process	protein O-linked glycosylation
F	0016020	cellular_component	membrane
F	0016266	biological_process	O-glycan processing
F	0016757	molecular_function	glycosyltransferase activity
F	0018242	biological_process	protein O-linked glycosylation via serine
F	0018243	biological_process	protein O-linked glycosylation via threonine
F	0030145	molecular_function	manganese ion binding
F	0030246	molecular_function	carbohydrate binding
F	0032580	cellular_component	Golgi cisterna membrane
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051604	biological_process	protein maturation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 701

Chain	Residue
A	ASP224
A	HIS226
A	HIS359
A	LR7702

---

site_id	AC2
Number of Residues	25
Details	binding site for residue LR7 A 702

Chain	Residue
A	GLY203
A	LEU204
A	ARG208
A	ASP224
A	SER225
A	HIS226
A	ALA253
A	ALA307
A	GLY308
A	GLY309
A	ALA310
A	VAL330
A	TRP331
A	GLY332
A	GLU334
A	VAL357
A	HIS359
A	ARG362
A	TYR367
A	MN701
A	THR143
A	PHE144
A	HIS145
A	ASP176
A	ARG201

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MN B 701

Chain	Residue
B	ASP224
B	HIS226
B	HIS359
B	LR7702

---

site_id	AC4
Number of Residues	26
Details	binding site for residue LR7 B 702

Chain	Residue
B	THR143
B	PHE144
B	HIS145
B	ASP176
B	ARG201
B	GLY203
B	LEU204
B	ARG208
B	ASP224
B	SER225
B	HIS226
B	ALA253
B	ALA307
B	GLY308
B	GLY309
B	ALA310
B	VAL330
B	TRP331
B	GLU334
B	ASN335
B	VAL357
B	HIS359
B	ARG362
B	TYR367
B	MN701
B	HOH805

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MN C 701

Chain	Residue
C	ASP224
C	HIS226
C	HIS359
C	LR7702

---

site_id	AC6
Number of Residues	23
Details	binding site for residue LR7 C 702

Chain	Residue
C	THR143
C	PHE144
C	ASP176
C	ARG201
C	GLY203
C	LEU204
C	ARG208
C	ASP224
C	SER225
C	HIS226
C	ALA307
C	GLY308
C	GLY309
C	ALA310
C	VAL330
C	TRP331
C	GLY332
C	GLU334
C	VAL357
C	HIS359
C	ARG362
C	TYR367
C	MN701

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MN D 701

Chain	Residue
D	ASP224
D	HIS226
D	HIS359
D	LR7702

---

site_id	AC8
Number of Residues	21
Details	binding site for residue LR7 D 702

Chain	Residue
D	HIS226
D	ALA253
D	ALA307
D	GLY308
D	GLY309
D	TRP331
D	GLU334
D	ASN335
D	HIS359
D	PHE361
D	TYR367
D	MN701
D	THR143
D	PHE144
D	ASP176
D	ARG201
D	GLY203
D	LEU204
D	ARG208
D	ASP224
D	SER225

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MN E 701

Chain	Residue
E	ASP224
E	HIS226
E	HIS359
E	LR7702

---

site_id	AD1
Number of Residues	23
Details	binding site for residue LR7 E 702

Chain	Residue
E	THR143
E	PHE144
E	HIS145
E	ASP176
E	ARG201
E	LEU204
E	ARG208
E	ASP224
E	SER225
E	HIS226
E	ALA253
E	ALA307
E	GLY308
E	GLY309
E	ALA310
E	VAL330
E	TRP331
E	GLU334
E	ASN335
E	VAL357
E	HIS359
E	ARG362
E	MN701

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MN F 701

Chain	Residue
F	ASP224
F	HIS226
F	HIS359
F	LR7702

---

site_id	AD3
Number of Residues	26
Details	binding site for residue LR7 F 702

Chain	Residue
F	THR143
F	PHE144
F	HIS145
F	ASP176
F	ARG201
F	LEU204
F	ARG208
F	ASP224
F	SER225
F	HIS226
F	CYS227
F	ALA307
F	GLY308
F	GLY309
F	ALA310
F	VAL330
F	TRP331
F	GLY332
F	GLU334
F	ASN335
F	VAL357
F	HIS359
F	ARG362
F	HIS365
F	TYR367
F	MN701

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-ARG6
B	MET1-ARG6
C	MET1-ARG6
D	MET1-ARG6
E	MET1-ARG6
F	MET1-ARG6

---

site_id	SWS_FT_FI2
Number of Residues	102
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
A	MET7-TYR24
B	MET7-TYR24
C	MET7-TYR24
D	MET7-TYR24
E	MET7-TYR24
F	MET7-TYR24

---

site_id	SWS_FT_FI3
Number of Residues	3276
Details	TOPO_DOM: Lumenal => ECO:0000255

Chain	Residue	Details
A	SER25-GLN571
B	SER25-GLN571
C	SER25-GLN571
D	SER25-GLN571
E	SER25-GLN571
F	SER25-GLN571

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9

Chain	Residue	Details
A	THR143
B	ARG201
B	SER225
B	TRP331
B	ARG362
B	HIS365
C	THR143
C	ASP176
C	ARG201
C	SER225
C	TRP331
A	ASP176
C	ARG362
C	HIS365
D	THR143
D	ASP176
D	ARG201
D	SER225
D	TRP331
D	ARG362
D	HIS365
E	THR143
A	ARG201
E	ASP176
E	ARG201
E	SER225
E	TRP331
E	ARG362
E	HIS365
F	THR143
F	ASP176
F	ARG201
F	SER225
A	SER225
F	TRP331
F	ARG362
F	HIS365
A	TRP331
A	ARG362
A	HIS365
B	THR143
B	ASP176

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9

Chain	Residue	Details
A	ASP224
D	ASP224
D	HIS226
D	HIS359
E	ASP224
E	HIS226
E	HIS359
F	ASP224
F	HIS226
F	HIS359
A	HIS226
A	HIS359
B	ASP224
B	HIS226
B	HIS359
C	ASP224
C	HIS226
C	HIS359

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJN, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9, ECO:0007744|PDB:5NDF, ECO:0007744|PDB:6EGS

Chain	Residue	Details
A	TYR367
B	TYR367
C	TYR367
D	TYR367
E	TYR367
F	TYR367

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	SITE: Not glycosylated

Chain	Residue	Details
A	ASN516
B	ASN516
C	ASN516
D	ASN516
E	ASN516
F	ASN516

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER536
B	SER536
C	SER536
D	SER536
E	SER536
F	SER536

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:37453717

Chain	Residue	Details
A	SER29
B	SER29
C	SER29
D	SER29
E	SER29
F	SER29

---