6NIP

Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 in complex with ZIKV E glycoprotein

Summary for 6NIP

• Entry DOI: 10.2210/pdb6nip/pdb
• Descriptor: MZ1 Heavy chain, MZ1 Light Chain, Envelope protein E (3 entities in total)
• Functional Keywords: zikv-denv, antibody, human, vaccination, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 190613.40

Authors

Sankhala, R.S.,Dussupt, V.,Donofrio, G.,Choe, M.,Modjarrad, K.,Michael, N.L.,Krebs, S.J.,Joyce, M.G. (deposition date: 2018-12-31, release date: 2019-12-25, Last modification date: 2023-10-11)

• Primary citation: Dussupt, V.,Sankhala, R.S.,Gromowski, G.D.,Donofrio, G.,De La Barrera, R.A.,Larocca, R.A.,Zaky, W.,Mendez-Rivera, L.,Choe, M.,Davidson, E.,McCracken, M.K.,Brien, J.D.,Abbink, P.,Bai, H.,Bryan, A.L.,Bias, C.H.,Berry, I.M.,Botero, N.,Cook, T.,Doria-Rose, N.A.,Escuer, A.G.I.,Frimpong, J.A.,Geretz, A.,Hernandez, M.,Hollidge, B.S.,Jian, N.,Kabra, K.,Leggat, D.J.,Liu, J.,Pinto, A.K.,Rutvisuttinunt, W.,Setliff, I.,Tran, U.,Townsley, S.,Doranz, B.J.,Rolland, M.,McDermott, A.B.,Georgiev, I.S.,Thomas, R.,Robb, M.L.,Eckels, K.H.,Barranco, E.,Koren, M.,Smith, D.R.,Jarman, R.G.,George, S.L.,Stephenson, K.E.,Barouch, D.H.,Modjarrad, K.,Michael, N.L.,Joyce, M.G.,Krebs, S.J.; Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.; Nat Med, 26:228-235, 2020; PubMed: 32015557; DOI: 10.1038/s41591-019-0746-2

Experimental method

X-RAY DIFFRACTION (4.16 Å)