6NIP

Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 in complex with ZIKV E glycoprotein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, H)	MZ1 Heavy chain	polymer	225	23927.8	2		Homo sapiens
2	B, F (B, L)	MZ1 Light Chain	polymer	216	22981.4	2		Homo sapiens
3	C, D (Z, E)	Envelope protein E	polymer	447	48397.5	2	UniProt (A0A024B7W1) Pfam (PF00869) Pfam (PF02832)	Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

Sequence modifications

Z, E: 1 - 405 (UniProt: A0A024B7W1)

PDB	External Database	Details
Gly 406	-	expression tag
Pro 407	-	expression tag
Leu 408	-	expression tag
Glu 409	-	expression tag
Val 410	-	expression tag
Leu 411	-	expression tag
Phe 412	-	expression tag
Gln 413	-	expression tag
Gly 414	-	expression tag
Pro 415	-	expression tag
Gly 416	-	expression tag
Ser 417	-	expression tag
Ala 418	-	expression tag
Trp 419	-	expression tag
Ser 420	-	expression tag
His 421	-	expression tag
Pro 422	-	expression tag
Gln 423	-	expression tag
Phe 424	-	expression tag
Glu 425	-	expression tag
Lys 426	-	expression tag
Gly 427	-	expression tag
Gly 428	-	expression tag
Gly 429	-	expression tag
Ser 430	-	expression tag
Gly 431	-	expression tag
Gly 432	-	expression tag
Gly 433	-	expression tag
Ser 434	-	expression tag
Gly 435	-	expression tag
Gly 436	-	expression tag
Gly 437	-	expression tag
Ser 438	-	expression tag
Ala 439	-	expression tag
Trp 440	-	expression tag
Ser 441	-	expression tag
His 442	-	expression tag
Pro 443	-	expression tag
Gln 444	-	expression tag
Phe 445	-	expression tag
Glu 446	-	expression tag
Lys 447	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	190613.4
All*	Total formula weight	190613.4

*Water molecules are not included.