6LYY
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation.
Summary for 6LYY
Entry DOI | 10.2210/pdb6lyy/pdb |
Related | 6LZ0 7CKO 7CKR 7DA5 |
EMDB information | 30019 30020 30389 30391 30623 |
Descriptor | Monocarboxylate transporter 1, Basigin, 3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione (3 entities in total) |
Functional Keywords | proton-coupled monocarboxylate transporter, mct1, basigin, anti-cancer, azd3965, bay-8002, 7acc2, single particle cryo-em, latate transporter, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 83763.30 |
Authors | |
Primary citation | Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C. Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184:370-, 2021 Cited by PubMed: 33333023DOI: 10.1016/j.cell.2020.11.043 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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