6LZ0

Cryo-EM structure of human MCT1 in complex with Basigin-2 in the presence of lactate

Summary for 6LZ0

• Entry DOI: 10.2210/pdb6lz0/pdb
• Related: 6LYY 7CKO 7CKR 7DA5
• EMDB information: 30019 30020 30389 30391 30623
• Descriptor: Monocarboxylate transporter 1, Basigin, (2S)-2-HYDROXYPROPANOIC ACID (3 entities in total)
• Functional Keywords: lactate transporter, mct1, basigin-2, proton-coupled monocarboxylate transporter, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 83337.87

Authors

Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Lei, J.,Yan, C. (deposition date: 2020-02-16, release date: 2020-12-23, Last modification date: 2024-03-27)

• Primary citation: Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C.; Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.; Cell, 184:370-, 2021; PubMed: 33333023; DOI: 10.1016/j.cell.2020.11.043

Experimental method

ELECTRON MICROSCOPY (3.3 Å)