6LYY
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005813 | cellular_component | centrosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0007098 | biological_process | centrosome cycle |
| A | 0008028 | molecular_function | monocarboxylic acid transmembrane transporter activity |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015129 | molecular_function | lactate transmembrane transporter activity |
| A | 0015130 | molecular_function | mevalonate transmembrane transporter activity |
| A | 0015141 | molecular_function | succinate transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015295 | molecular_function | solute:proton symporter activity |
| A | 0015650 | molecular_function | lactate:proton symporter activity |
| A | 0015718 | biological_process | monocarboxylic acid transport |
| A | 0015728 | biological_process | mevalonate transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030054 | cellular_component | cell junction |
| A | 0032094 | biological_process | response to food |
| A | 0035873 | biological_process | lactate transmembrane transport |
| A | 0035879 | biological_process | plasma membrane lactate transport |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042867 | biological_process | pyruvate catabolic process |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045202 | cellular_component | synapse |
| A | 0046943 | molecular_function | carboxylic acid transmembrane transporter activity |
| A | 0050796 | biological_process | regulation of insulin secretion |
| A | 0051780 | biological_process | behavioral response to nutrient |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071407 | biological_process | cellular response to organic cyclic compound |
| A | 0071422 | biological_process | succinate transmembrane transport |
| A | 0097159 | molecular_function | organic cyclic compound binding |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1901475 | biological_process | pyruvate transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1905039 | biological_process | carboxylic acid transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue EY0 A 601 |
| Chain | Residue |
| A | TYR34 |
| A | LEU305 |
| A | ASP309 |
| A | ARG313 |
| A | PHE367 |
| A | SER371 |
| A | LYS38 |
| A | LEU66 |
| A | TYR70 |
| A | MET151 |
| A | SER154 |
| A | PRO155 |
| A | LEU158 |
| A | LEU281 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA208-ILE228 | |
| A | ASN81-GLY84 | |
| A | THR133-ALA146 | |
| A | MET195-ARG261 | |
| A | LEU318-ARG328 | |
| A | GLU376-SER389 | |
| A | ASN444-VAL500 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P26453 |
| Chain | Residue | Details |
| B | TYR229-SER269 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER246 | |
| A | CYS106-VAL109 | |
| A | GLY170-TRP174 | |
| A | LYS289-SER295 | |
| A | SER350-TYR353 | |
| A | ARG411-TYR421 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER252 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
| Chain | Residue | Details |
| B | ASN44 | |
| B | ASN152 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN186 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | ASN147-PHE169 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | ARG175-LEU194 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | GLY262-GLY288 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | GLU296-GLY317 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | ILE329-LEU349 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | VAL354-PHE375 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | ALA390-GLY410 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO |
| Chain | Residue | Details |
| A | THR422-ILE443 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:6LZ0 |
| Chain | Residue | Details |
| A | LYS38 | |
| A | ARG313 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33333023, ECO:0007744|PDB:6LYY |
| Chain | Residue | Details |
| A | ASP309 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P53986 |
| Chain | Residue | Details |
| A | SER210 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER213 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P53986 |
| Chain | Residue | Details |
| A | THR231 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER461 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR466 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER467 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER483 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER498 |
