6KI6

Crystal structure of BCL11A in complex with gamma-globin -115 HPFH region

Summary for 6KI6

• Entry DOI: 10.2210/pdb6ki6/pdb
• Descriptor: B-cell lymphoma/leukemia 11A, DNA (5'-D(*AP*TP*AP*TP*TP*GP*GP*TP*CP*AP*AP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*TP*TP*GP*AP*CP*CP*AP*AP*TP*A)-3'), ... (5 entities in total)
• Functional Keywords: transcription factor, dna binding, transcription, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 41498.56

Authors

Li, F.D.,Yang, Y.,Shi, Y.Y. (deposition date: 2019-07-17, release date: 2019-09-11, Last modification date: 2024-03-27)

• Primary citation: Yang, Y.,Xu, Z.,He, C.,Zhang, B.,Shi, Y.,Li, F.; Structural insights into the recognition of gamma-globin gene promoter by BCL11A.; Cell Res., 29:960-963, 2019; PubMed: 31467406; DOI: 10.1038/s41422-019-0221-0

Experimental method

X-RAY DIFFRACTION (2.5 Å)