6KI6
Crystal structure of BCL11A in complex with gamma-globin -115 HPFH region
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | CYS744 |
| A | CYS747 |
| A | HIS760 |
| A | HIS764 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 902 |
| Chain | Residue |
| A | CYS772 |
| A | CYS775 |
| A | HIS788 |
| A | HIS792 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 903 |
| Chain | Residue |
| A | CYS805 |
| A | HIS818 |
| A | HIS823 |
| A | CYS802 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 901 |
| Chain | Residue |
| B | CYS744 |
| B | CYS747 |
| B | HIS760 |
| B | HIS764 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 902 |
| Chain | Residue |
| B | CYS775 |
| B | HIS788 |
| B | HIS792 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cey..CgkvFkncsnltvHrrs..H |
| Chain | Residue | Details |
| A | CYS744-HIS764 | |
| A | CYS772-HIS792 | |
| A | CYS802-HIS823 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type 5","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 23 |
| Details | Zinc finger: {"description":"C2H2-type 6","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"39423807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TLO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
