6I29
X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution
Summary for 6I29
Entry DOI | 10.2210/pdb6i29/pdb |
Related | 4DIJ |
Descriptor | Human E3 Ubiquitin-Protein Ligase MDM2, 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide (3 entities in total) |
Functional Keywords | lead optimization, ligase |
Biological source | Homo Sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 11890.73 |
Authors | Kallen, J. (deposition date: 2018-11-01, release date: 2019-11-20, Last modification date: 2024-01-24) |
Primary citation | Ornstein, J.,Iwamoto, Y.,Prytyskach, M.,Miller, M.,Kallen, J.,Ferretti, S.,Holzer, P.,Forrester, W.,Weissleder, R.,Lahav, G. p53 dynamics vary between tissues and are linked with radiation sensitivity To be published, |
Experimental method |
Structure validation
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