6I01

Structure of human D-glucuronyl C5 epimerase in complex with substrate

6I01 の概要

• エントリーDOI: 10.2210/pdb6i01/pdb
• 関連するPDBエントリー: 6HZZ 6I02
• 分子名称: D-glucuronyl C5-epimerase, CALCIUM ION, beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid, ... (11 entities in total)
• 機能のキーワード: c5-epimerase, heparan sulfate, isomerase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129442.74

構造登録者

Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Le Narvor, C.,Goulet, A.,Fadel, F.,Vives, R.R.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y. (登録日: 2018-10-24, 公開日: 2019-04-03, 最終更新日: 2024-01-24)

• 主引用文献: Debarnot, C.,Monneau, Y.R.,Roig-Zamboni, V.,Delauzun, V.,Le Narvor, C.,Richard, E.,Henault, J.,Goulet, A.,Fadel, F.,Vives, R.R.,Priem, B.,Bonnaffe, D.,Lortat-Jacob, H.,Bourne, Y.; Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.; Proc.Natl.Acad.Sci.USA, 116:6760-6765, 2019; PubMed: 30872481; DOI: 10.1073/pnas.1818333116

実験手法

X-RAY DIFFRACTION (2.1 Å)