Cryo-EM structure of the BRISC complex bound to SHMT2

Summary for 6H3C

EMDB information0132
DescriptorBRISC complex subunit Abraxas 2, Lys-63-specific deubiquitinase BRCC36, BRISC and BRCA1-A complex member 2, ... (7 entities in total)
Functional Keywordsdeubiquitinase complex, dub, lysine-63 linkage specific, brcc36-containing, brca1a binding, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains10
Total molecular weight458077.08
Bunker, R.D.,Rabl, J.,Thoma, N.H. (deposition date: 2018-07-18, release date: 2019-07-10)
Primary citation
Rabl, J.,Bunker, R.D.,Schenk, A.D.,Cavadini, S.,Gill, M.E.,Abdulrahman, W.,Andres-Pons, A.,Luijsterburg, M.S.,Ibrahim, A.F.M.,Branigan, E.,Aguirre, J.D.,Marceau, A.H.,Guerillon, C.,Bouwmeester, T.,Hassiepen, U.,Peters, A.H.F.M.,Renatus, M.,Gelman, L.,Rubin, S.M.,Mailand, N.,van Attikum, H.,Hay, R.T.,Thoma, N.H.
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol.Cell, 2019
PubMed: 31253574 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2019.06.002
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers2 0.4% 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures