6H2V

Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A resolution

Summary for 6H2V

DescriptorMethyltransferase-like protein 5, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYLMETHIONINE, ... (8 entities in total)
Functional Keywordsrrna maturation, methyltransferase, translation, ribosome synthesis, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight79685.67
Authors
van Tran, N.,Graille, M. (deposition date: 2018-07-16, release date: 2019-07-31, Last modification date: 2019-09-18)
Primary citation
van Tran, N.,Ernst, F.G.M.,Hawley, B.R.,Zorbas, C.,Ulryck, N.,Hackert, P.,Bohnsack, K.E.,Bohnsack, M.T.,Jaffrey, S.R.,Graille, M.,Lafontaine, D.L.J.
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.
Nucleic Acids Res., 47:7719-7733, 2019
PubMed: 31328227 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkz619
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.49 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2473 0.3% 7.2% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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