6H2V
Crystal structure of human METTL5-TRMT112 complex, the 18S rRNA m6A1832 methyltransferase at 2.5A resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001650 | cellular_component | fibrillar center |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005730 | cellular_component | nucleolus |
A | 0005829 | cellular_component | cytosol |
A | 0006364 | biological_process | rRNA processing |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
A | 0008988 | molecular_function | rRNA (adenine-N6-)-methyltransferase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0031167 | biological_process | rRNA methylation |
A | 0032259 | biological_process | methylation |
A | 0045727 | biological_process | positive regulation of translation |
A | 0048863 | biological_process | stem cell differentiation |
A | 0098793 | cellular_component | presynapse |
A | 0098794 | cellular_component | postsynapse |
A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
B | 0000470 | biological_process | maturation of LSU-rRNA |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006364 | biological_process | rRNA processing |
B | 0008276 | molecular_function | protein methyltransferase activity |
B | 0018364 | biological_process | peptidyl-glutamine methylation |
B | 0030488 | biological_process | tRNA methylation |
B | 0030490 | biological_process | maturation of SSU-rRNA |
B | 0031167 | biological_process | rRNA methylation |
B | 0032991 | cellular_component | protein-containing complex |
B | 0043528 | cellular_component | tRNA (m2G10) methyltransferase complex |
B | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
B | 0046982 | molecular_function | protein heterodimerization activity |
B | 0048471 | cellular_component | perinuclear region of cytoplasm |
B | 0070476 | biological_process | rRNA (guanine-N7)-methylation |
B | 0141106 | molecular_function | tRNA methyltransferase activator activity |
B | 2000234 | biological_process | positive regulation of rRNA processing |
C | 0001650 | cellular_component | fibrillar center |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005730 | cellular_component | nucleolus |
C | 0005829 | cellular_component | cytosol |
C | 0006364 | biological_process | rRNA processing |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
C | 0008988 | molecular_function | rRNA (adenine-N6-)-methyltransferase activity |
C | 0016740 | molecular_function | transferase activity |
C | 0031167 | biological_process | rRNA methylation |
C | 0032259 | biological_process | methylation |
C | 0045727 | biological_process | positive regulation of translation |
C | 0048863 | biological_process | stem cell differentiation |
C | 0098793 | cellular_component | presynapse |
C | 0098794 | cellular_component | postsynapse |
C | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
D | 0000470 | biological_process | maturation of LSU-rRNA |
D | 0005515 | molecular_function | protein binding |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006364 | biological_process | rRNA processing |
D | 0008276 | molecular_function | protein methyltransferase activity |
D | 0018364 | biological_process | peptidyl-glutamine methylation |
D | 0030488 | biological_process | tRNA methylation |
D | 0030490 | biological_process | maturation of SSU-rRNA |
D | 0031167 | biological_process | rRNA methylation |
D | 0032991 | cellular_component | protein-containing complex |
D | 0043528 | cellular_component | tRNA (m2G10) methyltransferase complex |
D | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
D | 0046982 | molecular_function | protein heterodimerization activity |
D | 0048471 | cellular_component | perinuclear region of cytoplasm |
D | 0070476 | biological_process | rRNA (guanine-N7)-methylation |
D | 0141106 | molecular_function | tRNA methyltransferase activator activity |
D | 2000234 | biological_process | positive regulation of rRNA processing |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue SAM A 301 |
Chain | Residue |
A | PHE19 |
A | GLY61 |
A | CYS62 |
A | VAL64 |
A | ASP81 |
A | ILE82 |
A | CYS107 |
A | ASP108 |
A | VAL109 |
A | ASN126 |
A | PRO128 |
A | LEU26 |
A | HOH401 |
A | GLU27 |
A | GLN28 |
A | TYR29 |
A | PRO30 |
A | THR31 |
A | GLY59 |
A | CYS60 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 302 |
Chain | Residue |
A | THR151 |
A | LYS175 |
A | ARG206 |
A | SER208 |
A | HIS211 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 303 |
Chain | Residue |
A | LYS175 |
A | HIS210 |
A | HIS211 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 304 |
Chain | Residue |
A | ARG32 |
A | PRO187 |
A | ALA188 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue PEG B 201 |
Chain | Residue |
A | GLU84 |
A | GLN106 |
B | PRO108 |
B | SER110 |
B | ILE113 |
B | ASN115 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue EDO B 202 |
Chain | Residue |
B | GLU90 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 203 |
Chain | Residue |
B | GLU36 |
B | PHE37 |
B | ARG82 |
site_id | AC8 |
Number of Residues | 20 |
Details | binding site for residue SAM C 301 |
Chain | Residue |
C | PHE19 |
C | LEU26 |
C | GLU27 |
C | GLN28 |
C | TYR29 |
C | PRO30 |
C | THR31 |
C | GLY59 |
C | CYS60 |
C | GLY61 |
C | CYS62 |
C | VAL64 |
C | ASP81 |
C | ILE82 |
C | CYS107 |
C | ASP108 |
C | VAL109 |
C | ASN126 |
C | PRO128 |
C | HOH401 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue PG0 C 302 |
Chain | Residue |
A | LYS132 |
A | ASN133 |
C | ARG32 |
C | PRO33 |
C | HIS34 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue SO4 C 303 |
Chain | Residue |
C | THR151 |
C | ARG206 |
C | SER208 |
C | HIS211 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue SO4 C 304 |
Chain | Residue |
C | LYS175 |
C | HIS210 |
C | HIS211 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue EDO D 201 |
Chain | Residue |
C | ASN91 |
C | ASP103 |
C | MET104 |
D | CME33 |
D | GLU92 |
D | ARG111 |
D | GLY112 |
D | PG0202 |
site_id | AD4 |
Number of Residues | 8 |
Details | binding site for residue PG0 D 202 |
Chain | Residue |
C | GLU95 |
D | GLU29 |
D | ARG31 |
D | CME33 |
D | ILE94 |
D | GLU95 |
D | ARG111 |
D | EDO201 |
site_id | AD5 |
Number of Residues | 3 |
Details | binding site for residue SO4 D 203 |
Chain | Residue |
B | ARG62 |
D | PHE37 |
D | ARG82 |
Functional Information from PROSITE/UniProt
site_id | PS00092 |
Number of Residues | 7 |
Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. VIMNPPF |
Chain | Residue | Details |
A | VAL123-PHE129 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"31328227","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H2V","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"31328227","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H2U","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"31328227","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H2V","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |